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Santa Cruz Biotechnology offers a variety of gene silencing products to target channel proteins via RNA interference (RNAi). Channel proteins, such as the ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase), exist as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients.

As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. To knockdown expression of channel proteins, Santa Cruz Biotechnology offers siRNA, shRNA plasmid and shRNA lentiviral particles.