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Santa Cruz Biotechnology offers a variety of gene silencing products to target homeodomain proteins via RNA interference (RNAi). Homeodomain proteins bind DNA in a specific manner, though the specificity of one homeodomain protein is not usually enough to recognize its desired target genes only.

To solve this problem, homeodomain proteins normally function in the promoter region of their target genes and complex with other transcription factors, which are often other homeodomain proteins. These complexes have a much higher target specificity than a single homeodomain protein. To knockdown expression of homeodomain proteins, Santa Cruz Biotechnology offers siRNA, shRNA plasmid and shRNA lentiviral particles.