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Santa Cruz Biotechnology offers a variety of gene silencing products to target transcriptional regulators via RNA interference (RNAi). Transcription factors are required for the initiation of transcription. They regulate transcription by binding to DNA at specific nucleotide sequences within promoters and enhancers.

Transcription factors, which may also bind to RNA polymerase or to other transcription factors, are involved in the preinitiation complex formation. Upstream transcription factors and inducible transcription factors all bind upstream of the initiation site to repress or stimulate transcription. Upstream factors are unregulated, while inducible factors require inhibition or activation. To knockdown expression of transcriptional regulators, Santa Cruz Biotechnology offers siRNA, shRNA plasmid and shRNA lentiviral particles. Popular transcriptional regulators that are targeted using RNAi technology include NFκB, NFAT, c-Jun and Stat.