Santa Cruz Biotechnology offers a variety of gene silencing products to target cell adhesion proteins via RNA interference (RNAi). Cell adhesion molecules (CAMs) influence cell growth, differentiation, embryogenesis, immune response and cancer metastasis by networking information from the extracellular matrix to the cell.
The four major families of cell adhesion molecules are immunoglobulin (Ig) superfamily (calcium-independent transmembrane glycoproteins), integrins (transmembrane non-covalently linked heterodimers of a and b subunits), calcium-dependent cadherins and divalent cation-dependent selectins. Mutation of CAM genes has been linked to several forms of cancer, effecting tumor growth and metastasis. Such important cell adhesion proteins include β-catenin, connexin, p120 and paxillin. To knockdown expression of cell adhesion proteins, Santa Cruz Biotechnology offers siRNA, shRNA plasmid and shRNA lentiviral particles.